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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy[8]. A high level of protein intake is found to maintain muscle strength, and so far, the effects of protein supplementation in elderly volunteers have been promising, with several studies reporting an increase in strength for at least a few weeks following the supplementation, suggesting that protein supplementation may act clinically to improve muscle function. In this study, men and women aged 50 to 75 years were matched for mean BMI, body composition, and physical fitness. Subjects were randomised to the low-protein or the high-protein diet and provided either either: 40 g dietary protein, 2, lgd 4033 illegal.3 g dietary protein or no protein for 6 weeks, lgd 4033 illegal. In the low-protein group, participants were advised to consume less than 1 g of protein per kilogram of bodyweight per day, lgd-4033 cancer. The total daily energy intake was estimated by multiplying the daily energy intake at dinner (30 kcal) and breakfast (1.2 kcal) by total daily energy expenditure for both meals. The participants were also tested for changes in lean body mass, fat mass and abdominal adiposity. Muscle strength, strength endurance and endurance peak velocity were measured at baseline and after 6 weeks of a combination of the low-protein diet (control group) and high-protein protein diet (CHO group), illegal lgd 4033. Lean body mass (LBM), lean mass (LBM 2 and LBM 3 ) and fat mass (LBM 2 −LBM 3 ) were examined as the secondary outcome variables, lgd 4033 2.5mg. We found that the CHO group had a mean ± standard deviation increase in the change in LBM of 0, lgd-4033 buy.7 ± 0, lgd-4033 buy.7 kg from baseline to 6 weeks (95% CI, −0, lgd-4033 buy.1 ± 0, lgd-4033 buy.0 kg; P = 0, lgd-4033 buy.05), and a mean ± standard deviation increase in LBM 2 from baseline to 6 weeks (95% CI, −0, lgd-4033 buy.7 ± 1, lgd-4033 buy.3 kg; P = 0, lgd-4033 buy.04), lgd-4033 buy. Compared with the low protein group, there was a significantly (P = 0.03) greater change in lean mass from baseline to 6 weeks among both groups (CHO group, −0.2 ± 1.3 kg; low-protein group, −0.7 ± 1.3 kg; P = 0.01). There was no significant difference in fat mass (LBM 2 and LBM 3 ) between the groups. After 6 weeks, the low protein group also had greater changes in LBM 2 −LBM 3 from baseline to 6 weeks (CHO group, −0, lgd 4033 strength gains.5 ± 2, lgd 4033 strength gains.8 kg; low-protein group, −
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